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LabChip GX Touch HT Nucleic Acid Analyzer

The LabChip® GX Touch™ nucleic acid analyzer leverages microfluidic technology enabling DNA and RNA quantitation and sizing to be done in seconds via automated capillary electrophoresis separation. It is optimal for:

  • Fast, high-throughput QC analysis of NGS libraries
  • NGS library preparation (smear and fragment analysis) and quality control
  • RNA and DNA fragment analysis (including cell-free DNA, DNA isolated from FFPE samples, and PCR-free libraries)
  • Quantitation and qualification for CRISPR fragment analysis
  • Screening nucleic acid source material for vaccine development
  • Characterization and QC of small RNA molecules and CRISPR/Cas9 gRNA
Product Variants
Part Number: CLS138162
Part #:
CLS138162
Part Number: CLS137031
Part #:
CLS137031

Specifications

21CFR Compatible
Yes
Brand
LabChip GX
LabChip GXII

References

  • Bagheri, H., Friedman, H., Shao, H., Chong, Y., Lo, C., Emran, F., . . . Peterson, A. (2018). TIE: A Method to Electroporate Long DNA Templates into Preimplantation Embryos for CRISPR-Cas9 Gene Editing. The CRISPR Journal,1(3), 223-229. doi:10.1089/crispr.2017.0020.
  • Chesnais, V., Ott, A., Chaplais, E., Gabillard, S., Pallares, D., Vauloup-Fellous, C., . . . Ginoux, E. (2018). Using massively parallel shotgun sequencing of maternal plasmatic cell-free DNA for cytomegalovirus DNA detection during pregnancy: A proof of concept study. Scientific Reports, 8(1). doi:10.1038/s41598-018-22414-6.
  • Costa, J-M., et al. (2018). Cell-free fetal DNA versus maternal serum screening for trisomy 21 in pregnant women with and without assisted reproduction technology: a prospective interventional study. Genetics in Medicine. doi:10.1038/gim.2018.4.
  • Faiz, A., Heijink, I. H., Vermeulen, C. J., Guryev, V., Berge, M. V., Nawijn, M. C., & Pouwels, S. D. (2018). Cigarette smoke exposure decreases CFLAR expression in the bronchial epithelium, augmenting susceptibility for lung epithelial cell death and DAMP release. Scientific Reports,8(1). doi:10.1038/s41598-018-30602-7.
  • Ford, L., Carter, G. P., Wang, Q., Seemann, T., Sintchenko, V., Glass, K., . . . Kirk, M. D. (2018). Incorporating Whole-Genome Sequencing into Public Health Surveillance: Lessons from Prospective Sequencing of Salmonella Typhimurium in Australia. Foodborne Pathogens and Disease, 15(3), 161-167. doi:10.1089/fpd.2017.2352.
  • Gergen, J., Coulon, F., Creneguy, A., Elain-Duret, N., Gutierrez, A., Pinkenburg, O., . . . Haspot, F. (2018). Multiplex CRISPR/Cas9 system impairs HCMV replication by excising an essential viral gene. Plos One, 13(2). doi:10.1371/journal.pone.0192602.
  • Giand et al. (2021) Early transmission of SARS-CoV-2 in South Africa: An epidemiological and phylogenetic report. International Journal of Infectious Diseases, 103, 234-241, doi.org/10.1016/j.ijid.2020.11.128.
  • Kim, K.W., et al. (2021) Respiratory viral co-infections among SARS-CoV-2 cases confirmed by virome capture sequencing. Sci Rep 11, 3934 doi.org/10.1038/s41598-021-83642-x.
  • Mogilevsky, M., Shimshon, O., Kumar, S., Mogilevsky, A., Keshet, E., Yavin, E., Heyd, F., and Karni, R. (2018) Modulation of MKNK2 alternative splicing by splice-switching oligonucleotides as a novel approach for glioblastoma treatment. Nucleic Acids Res. doi: 10.1093/nar/gky921.
  • Ong, J., Woldhuis, R. R., Boudewijn, I. M., Berg, A. V., Kluiver, J., Kok, K., . . . Brandsma, C. A. (2019). Age-related gene and miRNA expression changes in airways of healthy individuals. Scientific Reports,9(1). doi:10.1038/s41598-019-39873-0.
  • Raffaele, J., Loughney, J. W., & Rustandi, R. R. (2021). Development of a microchip capillary electrophoresis method for determination of the purity and integrity of mrna in lipid nanoparticle vaccines. ELECTROPHORESIS. doi.org/10.1002/elps.202100272.
  • Trolle, C., et al. (2016) Widespread DNA hypomethylation and differential gene expression in Turner syndrome. Scientific Reports (6). doi.org/10.1038/srep34220.

Resources

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1-6 of 9 Resources
Product Note Icon
Product Note
Automated integrity assessment of RNA samples.

LabChip® RNA analysis provides a fast and easy way to quantitate RNA samples ranging in size from 100 to 6,000.

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Whitepaper
Efficient multiplexed targeted gene editing as a strategy to generate improved CHO host cell lines for biotherapeutic manufacturing applications

The use of CRISPR-Cas9 tools for gene editing has opened new possibilities for the genetic optimization of biological systems with...

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Application Note
High-throughput, end-to-end Cell Free DNA (cfDNA) analysis workflow from plasma

Benefit of an automated cfDNA analysis workflow

The presence of double stranded, circulating cell free DNA (cfDNA) in blood plasma...

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Application Note
LabChip GX Touch platform applications in epigenetic studies

The LabChip GX Touch nucleic acid analyzer is an important component of Oxford BioDynamics research in epigenetic biomarkers of...

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Application Note
LabChip GXII Touch small RNA assay

The LabChip® Small RNA assay was developed for analysis of small RNAs 20-150 nucleotides (nt) long.

Together with LabChip® microflu...

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Whitepaper
Mouse tail genotyping: A LabChip application to assess the genetic modifications on mutant mouse populations.

This application note describes how researchers at two organizations utilized Revvity workflows for genotyping reaction setup and...

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