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T Cell Immunology

T cells play a pivotal role in combating infectious diseases

The immune system is a complex network of cells and proteins that defend the body against infection. Key cells like T cells, B cells, macrophages, dendritic cells and neutrophils work together to identify, eliminate, and neutralize pathogens. T cells can play an important role in the diagnosis and monitoring of infectious diseases.

T cells, or T lymphocytes, are important cells in the adaptive immune system, playing a central role in orchestrating almost all adaptive immune responses by1, 2:

  • Eliminating infected or cancerous cells
  • Mobilizing immune cells to mount robust immune responses
  • Developing a pathogen memory to prevent reinfection
  • Stimulating B cells to generate antibody responses

By utilizing an enzyme-linked immunospot (ELISPOT) assay, we can identify and analyze T cells responses to pathogens, allowing for the identification of T cells that are responsive to specific antigens.

T Cell Immunology

T-SPOT technology

T cell immunology T-spot technology

 

We have over 20 years of experience in T cell immunology and accurately measuring T cell responses using our T-SPOT technology. By leveraging the ELISPOT methodology to perform an interferon-gamma release assay (IGRA), it offers a refined analysis of individual immune responses to specific antigens.

The technology includes 3 crucial steps:

  1. Cell isolation: Extract the desired cell population (PBMCs) from whole blood
  2. Cell washing: Enables removal of potential interfering substances from whole blood
  3. Cell counting: Ensures the required number of cells are used to produce reportable and accurate results regardless of individual patient cell counts

Through this innovative technology, we demonstrate our commitment to pushing the boundaries of healthcare and harnessing the power of the immune system to enhance diagnostic accuracy and improve patient outcomes.

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Tuberculosis

For every person with active tuberculosis (TB), many more have a latent TB infection. Find out how Revvity are advancing TB management with the T-SPOT.TB test.

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For every person with active tuberculosis (TB), many more have a latent TB infection. Find out how Revvity are advancing TB management with the T-SPOT.TB test.

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Cytomegalovirus

Cytomegalovirus (CMV) is an opportunistic virus and common cause of morbidity and mortality in solid organ and hematopoietic stem cell transplant patients. To help assess a patient’s level of anti-CMV cell mediated immunity, Revvity have developed the T-SPOT.CMV test.

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Cytomegalovirus (CMV) is an opportunistic virus and common cause of morbidity and mortality in solid organ and hematopoietic stem cell transplant patients. To help assess a patient’s level of anti-CMV cell mediated immunity, Revvity have developed the T-SPOT.CMV test.

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SARS-CoV-2

CE marked for IVD use, the T-SPOT.COVID test was developed for use as an aid in identifying and monitoring individuals with a T cell immune response to COVID-19 vaccination or SARS-CoV-2 infection.

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CE marked for IVD use, the T-SPOT.COVID test was developed for use as an aid in identifying and monitoring individuals with a T cell immune response to COVID-19 vaccination or SARS-CoV-2 infection.

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Products may not be licensed in accordance with the laws in all countries. Please check with your local representative for availability. Revvity, Inc. does not endorse or make recommendations with respect to research, medication, or treatments. All information presented is for informational purposes only and is not intended as medical advice.

References:

  1. National Institute of Allergy and Infectious Diseases. Overview of the Immune System.
  2. Abbas AK, et al. Cellular and Molecular Immunology. 9th edition. Elsevier; 2017.

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